GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

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GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

The GPR30 is a novel estrogen receptor (ER) that is a candidate membrane ER based on its binding to 17β estradiol and its rapid signaling properties such as activation of the extracellular-regulated kinase (ERK) pathway. Its distribution in the mouse limbic system predicts a role for this receptor in the estrogenic modulation of anxiety behaviors in the mouse. A previous study showed that chron...

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ژورنال

عنوان ژورنال: Brain and Behavior

سال: 2013

ISSN: 2162-3279

DOI: 10.1002/brb3.197